No.

Polyquat is pretty much compatible with anything . . . well, except for anionic flocculants and the like. It *will* use up some chlorine -- chlorine breaks it down, though the stuff it breaks down into is still effective against algae. But, it's probably not especially efficient to use polyquat at the same time you are running really high chlorine.

However, it's ideal for use during any sort of effort to remove or manage metal problems.