Our pool was installed last year and it included the Nature 2. I wish I'd have known better because I would have saved myself some money. Based on what I read on the old board I decided not to use it. The cartridge is still in the box.
There were some people who used the Nature 2 and noticed no difference when they stopped. Seemed to me it was all down side (possible metals in the pool) and no documented up side.
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