Without more details, I can't answer absolutely. But in general, the mechanism by which you add chemicals will have ZERO influence on "the efficiency of granulars".
On the other hand, timing matters: add chlorine in the evening, and avoid adding 2 or more chemicals at one time . . . and you should be OK.
What REALLY improves efficiency is (1) using the RIGHT, BASIC, UNBLENDED chemical and avoiding unneeded chems, (2) adding the RIGHT amount, based on accurate testing, (3) never, EVER letting chlorine get low! (A single algae episode can use up a month's worth of chemicals . . . or more!
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