You would mix it with water and add it to the skimmer - for my DE filter I fill a bucket with a couple gallons of pool water and add the DE powder to it so you get a slurry, with the pump on you pour the DE slurry into the skimmer. I would try a gallon bucket maybe half full for the amount of DE that you want to add.
I haven't heard of putting DE in a cartridge filter, only a sand filter (and obviously a DE filter).
Be careful where you wash it off - when it dries the DE will be a powder once again and dangerous to breath.
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